Volume 12, Issue 6 (November & December - in Press 2021)                   BCN 2021, 12(6): 0-0 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akingbade G, Ijomone O, Adelakun S, Enaibe B. Histological and Biochemical Alterations in the Superior Colliculus and Lateral Geniculate Nucleus of Juvenile Rats Following Prenatal Exposure to Marijuana Smoke. BCN. 2021; 12 (6)
URL: http://bcn.iums.ac.ir/article-1-1429-en.html
1- Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology, Akure, Nigeria.
2- Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
Abstract:  
Prenatal exposure to marijuana has been associated with a variety of brain deficits, as Δ9-tetrahydrocannabinol (THC), its main active ingredient crosses the placenta and affects foetal brain development. Despite this effect, marijuana remains a commonly abused substance among pregnant women. In the current study, we examined the histological and biochemical changes in the superior colliculus (SC) and lateral geniculate nucleus (LGN) in rat brains prenatally exposed to marijuana. Four groups of pregnant rats (n = 5) were exposed to the smoke of 10 g/kg BW marijuana at various days during the 21-23 days duration of rat gestation, with a group (Control) which is not exposed. After parturition, the litters from each group were sacrificed by cervical dislocation on postnatal days 7, 14, and 21; and the superior colliculi and lateral geniculate nuclei were excised. Tissue sections were prepared for histological studies using Haematoxylin and Eosin stains. Biochemical studies were done on the activity levels of alkaline phosphatase, acid phosphatase, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase. Histological and biochemical analyses of tissues were performed. Prenatal exposure to marijuana resulted in spontaneous abortion as well as affected neuronal morphology in the SC and LGN of the progeny. Also, levels of enzyme activities were altered following maternal exposure to marijuana. These data suggests that histological changes in the SC and LGN is associated with oxidative damage.
 
     
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2019/02/14 | Accepted: 2019/07/28 | Published: 2018/03/15

References
1. Ahmed MF. Inner ear dysfunction in patients with Behcet's disease. The Egyptian Journal of Otolaryngology. 2017 Jan;33(1):78-83. [DOI:10.4103/1012-5574.199413]
2. Bayir O, Comoglu SS, Ozdek A, Aytac E, Guven H, Ozdal MP, Korkmaz H. Vestibular Evoked Myogenic Potential Responses in Behçet's Disease. The Journal of International Advanced Otology. 2012;8(1):113. https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.683.3885&rep=rep1&type=pdf
3. Pollak L, Luxon LM, Haskard DO. Labyrinthine involvement in Behçet's syndrome. The Journal of Laryngology & Otology. 2001 Jul;115(7):522-9. [DOI:10.1258/0022215011908315] [PMID]
4. Marshall SE. Behçet's disease. Best Practice & Research Clinical Rheumatology. 2004 Jun 1;18(3):291-311. [DOI:10.1016/j.berh.2004.02.008] [PMID]
5. Yazici H, Fresko I, Yurdakul S. Behçet's syndrome: disease manifestations, management, and advances in treatment. Nature clinical practice Rheumatology. 2007 Mar;3(3):148-55. [DOI:10.1038/ncprheum0436] [PMID]
6. Erbek S, Erbek SS, Yilmaz S, Yucel E, Ozluoglu LN. Vestibular evoked myogenic potentials in Behcet's disease. European archives of oto-rhino-laryngology. 2008 Nov;265(11):1315-20. [DOI:10.1007/s00405-008-0650-8] [PMID]
7. Yilmaz S, Simsek I, Cinar M, Erdem H, Kose O, Yazici Y, Pay S. Patient-driven assessment of disease activity in Behçet's syndrome: cross-cultural adaptation, reliability and validity of the Turkish version of the Behçet's Syndrome Activity Score. Clin Exp Rheumatol. 2013 May 1;31(3 Suppl 77):77-83. https://www.clinexprheumatol.org/article.asp?a=7307
8. Girasoli L, Cazzador D, Padoan R, Nardello E, Felicetti M, Zanoletti E, Schiavon F, Bovo R. Update on vertigo in autoimmune disorders, from diagnosis to treatment. Journal of immunology research. 2018 Sep 26;2018. [DOI:10.1155/2018/5072582] [PMID] [PMCID]
9. Davatchi F, JAMSHIDI AR, BANIHASHEMI AT, Gholami J, FOROUZANFAR MH, Moradi M, Akhlaghi MS, KHABAZI AR, SALARI AH, Salessi M, Karimifar M. Prevalence of Behcet's disease in Iran: a WHO‐ILAR COPCORD stage I study. APLAR Journal of Rheumatology. 2007 Sep;10(3):239-43. [DOI:10.1111/j.1479-8077.2007.00295.x]
10. Davatchi F, Shahram F, CHAMS‐DAVATCHI C, Shams H, Nadji A, Akhlaghi M, Faezi T, Ghodsi Z, Larimi R, Ashofteh F, Abdollahi BS. Behcet's disease in Iran: analysis of 6500 cases. International journal of rheumatic diseases. 2010 Oct;13(4):367-73. [DOI:10.1111/j.1756-185X.2010.01549.x] [PMID]
11. Shahram F, Nadji A, Jamshidi AR, Chams H, Chams C, Shafaie N, Akbarian M, GHARIB DF, Davatchi F. BEHCETS DISEASE IN IRAN, ANALYSIS OF 5,059 CASES. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=4490
12. Herdman SJ, Clendaniel R. Vestibular rehabilitation. FA Davis; 2014 Jul 24.
13. Kose E, Kamisli S, Dogan M, Tasolar S, Kahraman A, Oztanir MN, Sener S. The Evaluation of Vertebrobasilar Artery System in Neuro‐Behçet and Behçet Disease using Magnetic Resonance Angiography. The Anatomical Record. 2014 Jul;297(7):1302-5. https://doi.org/10.1002/ar.22922 [DOI:10.1002/ar.22922‏] [PMID]
14. Bayram A, Doğan M, Koç A, Kalkan M, Akçadağ A, Özcan İ. Cervical and ocular vestibular evoked myogenic potentials in Behcet's disease. American journal of otolaryngology. 2015 Jul 1;36(4):503-8. https://doi.org/10.1016/j.amjoto.2015.03.004 [DOI:10.1016/j.amjoto.2015.03.004‏] [PMID]
15. Evereklioglu C, Cokkeser Y, Doganay S, Er H, Kizilay A. Audio-vestibular evaluation in patients with Behçet's syndrome. The Journal of Laryngology & Otology. 2001 Sep;115(9):704-8. [DOI:10.1258/0022215011908946] [PMID]
16. Jacobson GP, Shephard NT. Balance function assessment and management: Plural Publishing; 2014.
17. Wuyts FL, Furman J, Vanspauwen R, Van de Heyning P. Vestibular function testing. Current opinion in neurology. 2007 Feb 1;20(1):19-24. doi: 10.1097/WCO.0b013e3280140808 [DOI:10.1097/WCO.0b013e3280140808] [PMID]
18. Baki NM, Zahran AM, Dabbous AO, Koura RA, Hamdy MM. Cervical vestibular evoked myogenic potential and high-frequency audiometry results in Behçet's disease. Egyptian Rheumatology and Rehabilitation. 2021 Dec;48(1):1-9. [DOI:10.1186/s43166-020-00052-z]
19. MacDougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP. Application of the video head impulse test to detect vertical semicircular canal dysfunction. Otology & Neurotology. 2013 Aug 1;34(6):974-9. https://doi.org/10.1097/MAO.0b013e31828d676d [DOI:10.1097/mao.0b013e31828d676d] [PMID]
20. Mangabeira Albernaz PL, Zuma e Maia FC. The video head impulse test. Acta oto-laryngologica. 2014 Dec 1;134(12):1245-50. [DOI:10.3109/00016489.2014.942439] [PMID]
21. Judge PD, Rodriguez AI, Barin K, Janky KL. Impact of target distance, target size, and visual acuity on the video head impulse test. Otolaryngology-Head and Neck Surgery. 2018 Oct;159(4):739-42. https://doi.org/10.1177/0194599818779908 [DOI:10.1177%2F0194599818779908] [PMID] [PMCID]
22. Ertugrul O, Mutlu A, Cam OH, Ozluoglu L. Audiological and vestibular measurements in Behçet's disease. European Archives of Oto-Rhino-Laryngology. 2019 Jun;276(6):1625-32. [DOI:10.1007/s00405-019-05403-x] [PMID]
23. Wuyts FL, Furman J, Vanspauwen R, Van de Heyning P. Vestibular function testing. Current opinion in neurology. 2007 Feb 1;20(1):19-24. https://doi.org/10.1097/WCO.0b013e3280140808 [DOI:10.1097/wco.0b013e3280140808] [PMID]
24. Jafarzadeh, S., Bahrami, E., Pourbakht, A., Jalaie, S., & Daneshi, A. Validity and reliability of the Persian version of the dizziness handicap inventory. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, (2014). 19(8), 769
25. TUTAR B, BERKİTEN G, KARAKETİR S, TUNA ÖB, UYAR Y, AKAN O. Evaluation of the Effect of Behçet's Disease on Vestibulo-Ocular Reflex with Video Head Impulse Test. Kulak Burun Boğaz ve Baş Boyun Cerrahisi. 2020;28(2):110-6. [DOI:10.24179/kbbbbc.2019-73123]
26. DeLong AP. Specificity of the Video Head Impulse Test System (Doctoral dissertation). http://hdl.handle.net/1803/12223
27. Jacobson, G. P., Shepard, N. T., Barin, K., Janky, K., & McCaslin, D. L. (Eds.). Balance function assessment and management. plural publishing (2020).
28. Hall JW. New handbook of auditory evoked responses. Pearson; 2007.
29. Kulahli I, Balci K, Koseoglu E, Yuce I, Cagli S, Senturk M. Audio-vestibular disturbances in Behcet's patients: report of 62 cases. Hearing research. 2005 May 1;203(1-2):28-31. [DOI:10.1016/j.heares.2004.11.020] [PMID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb