Volume 12, Issue 6 (November & December - in Press 2021)                   BCN 2021, 12(6): 0-0 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asaadi F, Faeghi F, Ashrafi F, Sanei Taheri M, Heidari M H. Clinical Significance of Diffusion Weighted Magnetic Resonance Imaging on Treatment Efficacy in MS Patients With Acute Attacks. BCN. 2021; 12 (6)
URL: http://bcn.iums.ac.ir/article-1-1353-en.html
1- Radiology Technology Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Neurology Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Radiology Department, Shohada Tajrish Hospital, Tehran, Iran
4- Department of Basic sciences,School of Allied Medical sciences, Shahid Beheshti University of Medical Sciences,Tehran, Iran
Abstract:  

Background: Despite the existence of various imaging methods, the accurate diagnosis of many neurodegenerative diseases is still controversial. The use of advanced imaging techniques, such as the diffusion weighted imaging can be help the early detection of MS and evaluation of the treatment efficacy in these patients.
Materials and method: 24 MS patients with acute attack and thirty healthy subjects were considered in our study. In the patients' group, ROI was defined for acute and chronic plaques and normal appearing white matter (NAWM). In the normal group, ROI only was mapped in the white matter in the same regions of the patient. All MS patients were receiving Methylprednisolone for 3 to 5 days. The rate of clinical disability in these patients was also evaluated based on Expanded Disability Status Scale (EDSS) index. Finally evaluate changes of ADC values of plaques and NAWM before and after treatment.
Results: The ADC values of acute plaques, ADC values of NAWM, number of enhancement in T1w and EDSS values showed a significant difference after treatment compared to before treatment. However, the ADC values of chronic plaques have not shown any significant difference after treatment. There was a significant positive correlation between the difference in EDSS values before and after treatment.
Conclusion: The results of study showed that using diffusion technique and ADC values analysis is a proper non-invasive method for MS diagnosis and evaluation of treatment efficacy in these patients.
     
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2018/10/20 | Accepted: 2020/01/4 | Published: 2021/11/19

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb