Volume 10, Issue 4 (July & August 2019)
BCN 2019, 10(4): 363-372 |
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Zamanian-Azodi M, Rezaei-Tavirani M, Robati R M. Introducing Genes With Significant Role in Migraine: An Interactomic Approach. BCN 2019; 10 (4) :363-372
URL: http://bcn.iums.ac.ir/article-1-1351-en.html
URL: http://bcn.iums.ac.ir/article-1-1351-en.html
1- Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers.
Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.
Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes.
Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine.
Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.
Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes.
Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine.
Type of Study: Original |
Subject:
Behavioral Neuroscience
Received: 2018/10/19 | Accepted: 2018/11/27 | Published: 2019/07/1
Received: 2018/10/19 | Accepted: 2018/11/27 | Published: 2019/07/1
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