Showing 4 results for Male
Mahmoud Hosseini, Azadeh Feizpour, Mohsen Rezaeipour, Atefeh Amani, Fatima Saffarzadeh, Esmaeil Farrokhi,
Volume 2, Issue 4 (8-2011)
Abstract
Introduction: The role of ovarian hormones and nitric oxide (NO) in learning and memory and their interaction has been widely investigated. The present study carried out to evaluate different effect of L-NAME on spatial learning and memory of ovariectomized (OVX) and sham operated rats.
Methods:
32 rats were divided into 4 groups: 1) Sham 2) OVX 3) Sham-LN and 4) OVX-LN. The animals of groups 3 and 4 were treated by L-NAME (10 mg/kg/ day) for 8 weeks while the animals of groups 1 and 2 received saline (1ml/kg/day) instead of L-NAME. The animals of all groups were then tested in Morris water maze during five days. The escape latency and traveled distance were compared between groups. Results:
Distance and time in OVX group was significantly higher than Sham group (p<0.01 and p<0.05). Time and distance in Sham-LN group was higher in comparison with Sham group (p<0.05 and p<0.01). There were no significant differences between OVX-LN and OVX groups in escape latency and traveled distance. Discussion:
The results of present study showed that removal of ovarian hormones could impair Morris water maze tskas includiong time and distance. Administarion of non specific nitricoxide inhibitor, L-NAME, affects Morrsi water maze tasks however, its effect is different in the absence and presence of ovarian hormones but it needs to be more investigated.
Omamuyovwi Meashack Ijomone, Ifechukwude Joachim Biose,
Volume 10, Issue 4 (7-2019)
Abstract
Introduction: We investigated the sexually dimorphic effects of Dextromethorphan (DM) on cognitive and depression-like behaviors as well as on hippocampal histology in rats following acute administration.
Methods: Wistar rats of both sexes were treated with 25 or 50 mg/kg of DM for 7 days via intraperitoneal injection. At the end of the administration, behavioral studies were performed on the Tail Suspension Test (TST) for depressive-like behaviors and the Y-maze for cognitive behaviors. The rats’ brains were excised and processed for routine histological analysis.
Results: Our results showed that DM significantly increased (P<0.05) immobility time in the TST in male rats but not female ones, and decreased percentage alternation (P<0.001) on the Y-maze in both male and female rats. Histological analysis revealed no morphological changes in the hippocampus following DM treatment.
Conclusion: DM impairs cognitive functions in both male and female rats without histologic defects in the hippocampus. However, the induced depressive-like behaviors following DM administration may be sexually dependent.
Mohammad Amin Rajizadeh, Khadijeh Esmaeilpour, Sina Motamedy, Fatemeh Mohtashami Borzadaranb, Vahid Sheibani,
Volume 11, Issue 5 (9-2020)
Abstract
Introduction: Previous studies demonstrated that forced and voluntary exercise had ameliorative effects on behavioral tasks followed by Sleep Deprivation (SD) in intact female rats. The main goal of this research was evaluating the impact of voluntary exercise on cognitive functions while SD and ovariectomization is induced in female wistar rats.
Methods: The rats were anesthesized combining dosage of ketamine and xylazine. Then, both ovaries were eliminated and 3 weeks after surgery the animals entered the study. The exercise protocol took 4 weeks of voluntary exercise in a wheel which was connected to home cage. For inducing a 72 hours deprivation the multiple platforms was applied. The cognitive functions were studied by exploiting the Morris Water Maze (MWM) and Novel object recognition tests. Anxiety was evaluated by open field test and corticostrone measurement was carried out by ELISA method. One-way and two-way ANOVA and repeated measures were utilized for data analysis and P<0.05 was considered statistically significant.
Results: We observed significant spatial and recognition learning and memory impairments in OVX sleep-deprived rats compared to the control group and voluntary exercise alleviated the SD-induced learning and memory defects.
Conclusion: We concluded that voluntary exercise can improve cognitive impairments followed by SD in OVX female rats.
Hossein Ali Ebrahimi, Mandana Jafari, Narges Khanjani, Najmeh Moradi,
Volume 13, Issue 3 (5-2022)
Abstract
Introduction: Neuropathy is a condition in which the Peripheral Nervous System (PNS) is disordered. Studying the effects of antioxidants on the performance improvement of this system is vital. This study aimed to investigate the effects of date extract on Nerve Conduction Velocity (NCV), Distal Motor Latency (DML), and wave height of the sciatic nerve in male rats.
Methods: This laboratory study used 24 male Wistar rats weighing 250-300 g, divided into the test and control groups. The test group received 10% date extract daily, at 4 mL /kg of body weight, for three weeks. In the beginning, nerve Conduction Velocity (NCV), Distal Motor Latency (DML), and wave height of the sciatic nerve were examined in all animals and re-examined for NCV three weeks later. P-values lower than 0.05 were considered significant.
Results: Sciatic NCV and wave height were significantly increased; however, compared to the control group, DML of the knee significantly declined in the test group.
Conclusion: The compositions of date extract accelerate electrical signal transmission.
