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Abbas Haghparast, Mehdi Ordikhani-Seyedlar, Maryam Ziaei, Pegah Azizi, Mohammad Ebrahimzadeh-Sarvestani,
Volume 1, Issue 4 (Summer 2010 -- 2010)
Abstract

A B S T R A C T

Introduction: The nucleus cuneiformis (NCF) and ventrolateral periaqueductal gray (vlPAG), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (NRM).

 Methods: This study examined whether the antinociceptive effect of morphine microinjected into the NCF is influenced by inactivation of vlPAG and NRM in rats. Animals were bilaterally microinjected with morphine (2.5 µg/0.3 µl saline) into the NCF. Electrolytic lesions were made in vlPAG (0.1 mA, 45 sec) and/or NRM (1 mA, 30 sec). Tail-flick latency (TFL) was measured at 30, 60, 90 and 120 min after microinjection.

 Results: The results showed that TFLs are significantly decreased in vlPAG+NRM lesions group at 30 (P<0.001) and 60 (P<0.01) min after intra- NCF administration of morphine whereas TFLs did not affect in solely vlPAG lesion animals. Our findings show that concurrent lesions of NRM and vlPAG completely reversed the analgesic effect of morphine in NCF. However, vlPAG do not play a critical role directly in pain modulatory system elicited from NCF, at least at the level of morphine-induced analgesia.

 Discussion: It can be concluded that its interactive effect in descending pain modulation from NCF to NRM should not be neglected.


Maryam Ziaei, Mansoureh Togha, Elham Rahimian, Jonas Persson,
Volume 10, Issue 1 (January & February 2019)
Abstract

Introduction: Converging evidence suggests that both emotional and cognitive processes are critically involved in moral judgment, and may be mediated by discrete parts of the prefrontal cortex. The current study aimed at investigating the mediatory effect of right Frontopolar Cortex (rFPC) on the way that emotions affect moral judgments. 
Methods: Six adult patients affected by rFPC and 10 healthy controls were included in the study. Participants made judgements on moral dilemmas after being shown either neutral or emotional pictures. The role of rFPC in executive control and emotional experience was also examined.
Results: The study results showed that inducing an emotional state increased the number of utilitarian responses both in the patients and controls. However, no significant differences were observed between the patients and controls in response time or the number of utilitarian responses. Also, no significant differences were observed in personal and impersonal dilemmas before and after the emotion induction in intergroup comparisons. Results of the executive control tasks showed reduced performance in patients affected by rFPC compared with the controls. 
Conclusion: The results of the current study suggested that rFPC might not have a direct role in mediating emotional processes during moral judgments, but possibly this region is important in a network supporting executive control functions.


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