Volume 13, Issue 5 (September & October 2022)
BCN 2022, 13(5): 609-624 |
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Yousefifard M, Janzadeh A, Mohamed Ali K, Vazirizadeh-Mahabadi M H, Sarveazad A, Madani Neishaboori A et al . Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis. BCN 2022; 13 (5) :609-624
URL: http://bcn.iums.ac.ir/article-1-2074-en.html
URL: http://bcn.iums.ac.ir/article-1-2074-en.html
Mahmoud Yousefifard1 
, Atousa Janzadeh2 , Kosar Mohamed Ali3 , Mohammad Hossein Vazirizadeh-Mahabadi4 , Arash Sarveazad5 , Arian Madani Neishaboori6 , Mostafa Hosseini * 7
, Atousa Janzadeh2 , Kosar Mohamed Ali3 , Mohammad Hossein Vazirizadeh-Mahabadi4 , Arash Sarveazad5 , Arian Madani Neishaboori6 , Mostafa Hosseini * 7
1- Department of Physiology, Researcher at Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Respiratory Medicine, School of Medicine, University of Sulaimani, Sulaimani, Iraq.
4- Researcher at Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
5- Colorectal Research Center, Researcher at Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran.
6- Researcher at Physiology Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
7- Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2- Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Respiratory Medicine, School of Medicine, University of Sulaimani, Sulaimani, Iraq.
4- Researcher at Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
5- Colorectal Research Center, Researcher at Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran.
6- Researcher at Physiology Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
7- Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI).
Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI).
Results: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment.
Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy.
Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI).
Results: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment.
Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy.
Type of Study: Review |
Subject:
Clinical Neuroscience
Received: 2021/01/23 | Accepted: 2021/06/12 | Published: 2022/09/11
Received: 2021/01/23 | Accepted: 2021/06/12 | Published: 2022/09/11
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