Volume 8, Issue 4 (July & August 2017 -- 2017)                   BCN 2017, 8(4): 337-343 | Back to browse issues page

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Almasi M, Motamed M R, Mehrpour M, Haghi-Ashtiani B, Haji Akhondi F, Nilipour Y et al . A Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case. BCN 2017; 8 (4) :337-343
URL: http://bcn.iums.ac.ir/article-1-710-en.html
1- Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Pediatric Pathology Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus.
Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy.
Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2016/11/5 | Accepted: 2017/02/18 | Published: 2017/07/1

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