Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats

Soleimani Asl, Sara; Falahati, Peiman; shekar riz, Nima; Molavi, Nima; Esmaeili, Farzaneh; Azimi, Zahra; Sajadi, Freidoon; Hayat, Parisa; Samzadeh-Kermani, Alireza; Mehdizadeh, Mehdi

Volume 3, Issue 1 (Autumn 2011 -- 2011) BCN 2011, 3(1): 44-47 | Back to browse issues page

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Soleimani Asl S, Falahati P, shekar riz N, Molavi N, Esmaeili F, Azimi Z, et al . Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats. BCN 2011; 3 (1) :44-47
URL: http://bcn.iums.ac.ir/article-1-198-en.html

Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats

Sara Soleimani Asl ^*

, Alireza Samzadeh-Kermani

, Mehdi Mehdizadeh

Abstract:

Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis.

Methods:

21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method.

Results:

The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis.

Discussion:

The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.

Keywords: Apoptosis, N-Methyl-3, 4-Methylenedioxyamphetamine, Acetylcysteine

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Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/03/29 | Published: 2011/10/15

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