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Salari Zare M, Mir M, Shobeiri S S, Tehrani H, Amiri P, Aldaghi M A et al . Determining Pro-oxidant Antioxidant Balance in Febrile Children With and Without Seizure: A Comparative Study. BCN 2025; 16 (3) :657-666
URL: http://bcn.iums.ac.ir/article-1-2942-en.html

Introduction: A benign condition known as a febrile seizure (FS) occurs between the ages of six and 60 months when the patient has a fever of at least 38 °C, is not suffering from a central nervous system (CNS) infection or metabolic disorder, and has no prior history of FSs. Oxidative stress is thought to contribute to the emergence of several neurodegenerative disorders. Therefore, the current study aimed to investigate the pro-oxidant-antioxidant balance (PAB) in febrile children with and without seizures.
Methods: This cross-sectional study was conducted at Heshmatieh Hospital, Sabzevar University of Medical Sciences, between March 2020 and March 2021. Forty febrile children with a temperature of 38 °C and above (F) and 40 febrile children who experienced FS were included in the study. Blood samples were collected from all patients. PAB was evaluated using a special PAB assay. The pro-oxidant-antioxidant ratio values were expressed in HK units.
Results: The HK variable in the FS group was 180.43±9.28 and 131.83±17.73 in the F group. The FS group had a higher mean serum level of PAB than the F group (P<0.05), indicating that the level of oxidative stress in patients with FSs was higher than in febrile patients without seizures.
Conclusion: Serum antioxidant levels appear to interiorize the risk of seizures in febrile children.