Volume 11, Issue 6 (November & December 2020)                   BCN 2020, 11(6): 765-772 | Back to browse issues page


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Simani L, Rezaei O, Ryan F, Sadeghi M, Hooshmandi E, Ramezani M et al . Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients. BCN. 2020; 11 (6) :765-772
URL: http://bcn.iums.ac.ir/article-1-1356-en.html
1- Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
3- Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:  
Introduction: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear.
Methods: The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. 
Results: A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels.
Conclusion: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.
Full-Text [PDF 660 kb]      
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2018/10/27 | Accepted: 2019/04/23 | Published: 2020/11/1

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