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1- Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, 1650 Cedar Ave., Montreal, Quebec, Canada
3- Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:  
Purpose: Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and reactive oxygen species (ROS) production, however, the impact of CoQ10 on seizure characteristics in epileptic patients is not clear.
Methods: The current study enrolled patients with the epileptic seizure (ES) to evaluate the serum concentration of CoQ10 with the aim to investigate whether a relationship exists between CoQ10 levels with duration, frequency, and type of seizure.
Results: A total of 39 patients with epileptic seizure and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs. 16.48±4.20 P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels.
Conclusion: These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2018/10/27 | Accepted: 2019/04/23

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