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1- Centre for Research in Addiction (CentRenA), University of Sultan Zainal Abidin, 21300 Kuala Terengganu, Terengganu; Malaysia
N-Methyl-3, 4-methylenedioxyamphetamine (MDMA) or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body systems which requires more findings on its mechanism of actions and the choice of treatments. MDMA provides an immediate enjoyable feeling by stimulating the neurotransmitters release such as dopamine and serotonin in the brain. Unfortunately, abnormal regulation of the brain neurotransmitters, as well as the increase of oxidative stress, causes damage to the neuronal brain after the MDMA exposure. To date, only a few studies have been done regarding on its treatment. Thus, the treatments for the MDMA consequences need to be further explored mainly by targeting on its mechanism of action in the brain system. Hence, this article presents a short review regarding the recent findings relating to the role of neurotransmitters in the cause of MDMA neurotoxicity.  It will be useful for the future research in the elucidating the potential treatment based on the targeted mechanisms to treat the neurotoxic effects of MDMA.
Type of Study: Review | Subject: Clinical Neuroscience
Received: 2018/07/24 | Accepted: 2019/02/19 | Published: 2018/03/15

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