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1- Shahid Chamran University, Ahvaz, Iran.
Abstract:  
Introduction: Donepezil (DON) is an acetylcholinesterase inhibitor (AChEIs) that has demonstrated efficacy in improving cogni­tive function and providing neuroprotective effects. This study evaluates the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of rat model of Alzheimerʻs disease.
Methods: In this experimental study, adult male wistar rats were divided into 4 groups: NBM lesion group which received electrically- induced lesion (0.5 m A, 3s) in NBM and donepezil groups (lesion + 5, 10, 15 mg/kg). Neuronal spontaneous activity to injection of the donepezil and saline were recorded in CA1 region of hippocampal.
Results: The results showed that i.p injection of donepezil (10, 15 mg/kg) increased neuronal spontaneous activity in rat model of Alzheimerʻs disease. Conclusion:  Results of this study suggest that acute IP injection of donepezil increased neuronal response in CA1 region of hippocampal in rat model of Alzheimerʻs disease.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/04/30 | Accepted: 2018/11/10 | Published: 2018/11/28

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