The quality of life (QOL) has been de.ned as ‘‘a person’s sense of well-being that stems from satisfaction or dissatisfaction with the areas of life that are important to him/her’’.  Age was also signi.cantly associated with several functional limitations such as illness, and physical restrictions. The concept of ‘‘resilience’’ refers to successful adaptation that unfolds within a context of signi.cant and usually debilitating adversity or life stress. The ability to adapt to pain may play an important role in maintaining the QOL. In this study, we investigated the role of resilience and age in various domains of quality of life such as physical, psychological, social and environmental domains. In this study, 290 adult patients (146 men, 144 women) completed the Connor-Davidson Resilience Scale and the WHOQOL-BREF questionnaire. Moreover, we illustrated several demographic variables. The results were analyzed using SPSS version 19.0 and means, descriptive correlation and regression were calculated. Our data revealed that resilience and age could signi.cantly anticipate the QOL and physical aspect (P<0.001). In psychological, social and environmental domains resilience but not the age could signi.cantly predict this domains. In addition, it is noticeable that the effect of resilience on the prediction of QOL is much more obvious in the psychological domain.. In conclusion, resilience is more important factor than the age in prediction of life quality (QOL) in persons suffering from chronic pain.