دوره 15، شماره 5 - ( 6-1403 )
جلد 15 شماره 5 صفحات 0-0 |
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Arumugam M, Sugumar S, Shah S, Hazeena P, Avadhani D, Murugan P. Evidence for Immune Dysregulation in Migraine Pathophysiology: A Preliminary Meta-analysis of Regulatory T-cell Reduction in Migraine Patients. BCN 2024; 15 (5)
URL: http://bcn.iums.ac.ir/article-1-2727-fa.html
URL: http://bcn.iums.ac.ir/article-1-2727-fa.html
Evidence for Immune Dysregulation in Migraine Pathophysiology: A Preliminary Meta-analysis of Regulatory T-cell Reduction in Migraine Patients. مجله علوم اعصاب پایه و بالینی. 1403; 15 (5)
چکیده:
Background & Objectives
The etiology of migraine is not fully understood, but there is ongoing debate about the potential role of immune dysfunction in migraine pathophysiology. Some clinical studies have shown a reduction in CD4+CD25+ Regulatory T cells (Treg) in migraine patients compared to healthy volunteers. However, these studies have not been systematically analyzed. The primary objective of this study is to conduct a systematic review of Treg level changes in migraine patients.
Methods
A detailed literature search was conducted on PubMed, Scopus, Embase, ProQuest, Cochrane review, Clinical trials, Academic thesis, American Academy of Neurology resources and Google Scholar databases from 2010 to 2023. Studies that were appropriately designed to quantify Treg levels in migraine patients were included in this meta-analysis.
Results
Out of 17 studies initially reviewed, only 4 studies with a total of 121 migraine patients were included for analysis. The meta-analysis revealed a statistically significant reduction in Treg levels in migraine patients compared to healthy volunteers (Z=1.21; p=0.23).
Conclusion
The observation of lower levels of Treg in migraine patients, compared to healthy volunteers, provides support for the theory that migraine may be an autoimmune disorder. However, to fully understand the role of immune dysregulation in migraine pathogenesis, additional clinical data is required. This is the first meta-analysis of Treg levels in the context of migraine research, adding a significant contribution to the existing literature on the topic.
The etiology of migraine is not fully understood, but there is ongoing debate about the potential role of immune dysfunction in migraine pathophysiology. Some clinical studies have shown a reduction in CD4+CD25+ Regulatory T cells (Treg) in migraine patients compared to healthy volunteers. However, these studies have not been systematically analyzed. The primary objective of this study is to conduct a systematic review of Treg level changes in migraine patients.
Methods
A detailed literature search was conducted on PubMed, Scopus, Embase, ProQuest, Cochrane review, Clinical trials, Academic thesis, American Academy of Neurology resources and Google Scholar databases from 2010 to 2023. Studies that were appropriately designed to quantify Treg levels in migraine patients were included in this meta-analysis.
Results
Out of 17 studies initially reviewed, only 4 studies with a total of 121 migraine patients were included for analysis. The meta-analysis revealed a statistically significant reduction in Treg levels in migraine patients compared to healthy volunteers (Z=1.21; p=0.23).
Conclusion
The observation of lower levels of Treg in migraine patients, compared to healthy volunteers, provides support for the theory that migraine may be an autoimmune disorder. However, to fully understand the role of immune dysregulation in migraine pathogenesis, additional clinical data is required. This is the first meta-analysis of Treg levels in the context of migraine research, adding a significant contribution to the existing literature on the topic.
نوع مطالعه: Review |
موضوع مقاله:
Cellular and molecular Neuroscience
دریافت: 1402/3/21 | پذیرش: 1403/6/24 | انتشار: 1403/6/30
دریافت: 1402/3/21 | پذیرش: 1403/6/24 | انتشار: 1403/6/30
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