دوره 14، شماره 4 - ( 5-1402 )                   جلد 14 شماره 4 صفحات 500-491 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nahtani M, Siahi M, Razjouyan J. Astrocytic-based Controller Shifts Epileptic Activity to the Chaotic State. BCN 2023; 14 (4) :491-500
URL: http://bcn.iums.ac.ir/article-1-2120-fa.html
Astrocytic-based Controller Shifts Epileptic Activity to the Chaotic State. مجله علوم اعصاب پایه و بالینی. 1402; 14 (4) :491-500

URL: http://bcn.iums.ac.ir/article-1-2120-fa.html


چکیده:  
Introduction: Investigating an effective controller to shift hippocampal epileptic periodicity to normal chaotic behavior will be new hope for epilepsy treatment. Astrocytes nourish and protect neurons and maintain synaptic transmission and network activity. Therefore, this study explored the ameliorating effect of the astrocyte computational model on epileptic periodicity. 
Methods: Modified Morris-Lecar equations were used to model the hippocampal CA3 network. Network inhibitory parameters were employed to generate oscillation-induced epileptiform periodicity. The astrocyte controller was based on a functional dynamic mathematical model of brain astrocytic cells.
Results: Results demonstrated that the synchronization of two neural networks shifted the brain’s chaotic state to periodicity. Applying an astrocytic controller to the synchronized networks returned the system to the desynchronized chaotic state.
Conclusion: It is concluded that astrocytes are probably a good model for controlling epileptic periodicity. However, more research is needed to delineate this effect. 
نوع مطالعه: Original | موضوع مقاله: Computational Neuroscience
دریافت: 1398/12/19 | پذیرش: 1400/3/2 | انتشار: 1402/4/10

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Basic and Clinical Neuroscience می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb