Jameie S B, Pirasteh A, Naseri A, Jameie M S, Farhadi M, Fahanik Babaee J et al . β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol. BCN 2021; 12 (3) :383-394
URL:
http://bcn.iums.ac.ir/article-1-1820-fa.html
β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol. مجله علوم اعصاب پایه و بالینی. 1400; 12 (3) :383-394
URL: http://bcn.iums.ac.ir/article-1-1820-fa.html
چکیده:
Introduction: The increasing cases of Alzheimer Disease (AD) has caused numerous problems. The risk of developing AD increases in menopausal women, too. Apigenin and β-estradiol are effective antioxidant and neuroprotective agents. We conducted the present study to explore their combined effects on β-amyloid plaque formation, memory, and learning in ovariectomized rats.
Methods: Forty-two Wistar rats were randomly assigned into 6 groups: 1) ovariectomized (OVX), 2) OVX + apigenin, 3) OVX + β-estradiol, 4) OVX + apigenin + β-estradiol, 5 &6) vehicle shams for E2 and API , and 7) surgical sham. Treatment was done with apigenin and β-estradiol. Then, we studied the formation of β-amyloid plaques, neuronal density in the hippocampus area, apoptosis, memory, and learning.
Results: Findings showed the significant formation of β-amyloid plaques in the hippocampus of OVX animals and their memory impairment. Apigenin and β-estradiol significantly reduced the number of β-amyloid plaques, as well as the symptoms of memory impairment and learning, and decreased the expression of caspase-3 in treated animals.
Conclusion: Accordingly, β-estradiol and apigenin could have more potent therapeutic effects on AD.
نوع مطالعه:
Original |
موضوع مقاله:
Behavioral Neuroscience دریافت: 1399/3/23 | پذیرش: 1399/5/19 | انتشار: 1400/2/11