دوره 12، شماره 6 - ( 8-1400 )
جلد 12 شماره 6 صفحات 804-789 |
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Tahamtan M, Nazari A, Aghaei I, Shabani M. Ischemic Postconditioning Attenuates Bilateral Renal Ischemia-induced Cognitive Impairments. BCN 2021; 12 (6) :789-804
URL: http://bcn.iums.ac.ir/article-1-1559-fa.html
URL: http://bcn.iums.ac.ir/article-1-1559-fa.html
Ischemic Postconditioning Attenuates Bilateral Renal Ischemia-induced Cognitive Impairments. مجله علوم اعصاب پایه و بالینی. 1400; 12 (6) :789-804
چکیده:
Introduction: Acute Kidney Injury (AKI) is a frequent complication of kidney failure with high mortality, leading to brain dysfunction. This study aimed to investigate the possible protective effect of Ischemic Postconditioning (IPo) against brain dysfunction induced by Bilateral Renal Ischemia (BRI).
Methods: Male Wistar rats underwent BRI, sham, or IPo surgery 24h and 1w after reperfusion. The rats’ explorative behaviors and motor function were evaluated by an open field, rotarod, and wire grip tests. The cognitive function was assessed by passive avoidance learning and Morris water maze tests. Western blotting was performed to evaluate hippocampal Brain-Derived Neurotrophic Factor (BDNF) expression.
Results: The impairment of balance function induced by BRI was not reversed; however, passive avoidance learning impairment was reversed by postconditioning 24h after reperfusion. IPo increased muscle strength compared to the BRI group; however, explorative behaviors and balance function had no difference 1w after reperfusion. BRI significantly decreased the BDNF protein expression in the hippocampus, and postconditioning increased 24h after reperfusion.
Conclusion: The obtained results demonstrated the deleterious effect of BRI on cognitive and balance function 24h after reperfusion. IPo indicated a curative effect against cognitive dysfunction probably by enhancing BDNF protein expression in the hippocampus.
Methods: Male Wistar rats underwent BRI, sham, or IPo surgery 24h and 1w after reperfusion. The rats’ explorative behaviors and motor function were evaluated by an open field, rotarod, and wire grip tests. The cognitive function was assessed by passive avoidance learning and Morris water maze tests. Western blotting was performed to evaluate hippocampal Brain-Derived Neurotrophic Factor (BDNF) expression.
Results: The impairment of balance function induced by BRI was not reversed; however, passive avoidance learning impairment was reversed by postconditioning 24h after reperfusion. IPo increased muscle strength compared to the BRI group; however, explorative behaviors and balance function had no difference 1w after reperfusion. BRI significantly decreased the BDNF protein expression in the hippocampus, and postconditioning increased 24h after reperfusion.
Conclusion: The obtained results demonstrated the deleterious effect of BRI on cognitive and balance function 24h after reperfusion. IPo indicated a curative effect against cognitive dysfunction probably by enhancing BDNF protein expression in the hippocampus.
نوع مطالعه: Original |
موضوع مقاله:
Behavioral Neuroscience
دریافت: 1398/4/29 | پذیرش: 1399/3/25 | انتشار: 1400/8/10
دریافت: 1398/4/29 | پذیرش: 1399/3/25 | انتشار: 1400/8/10
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