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Bekara A, Amazouz A, Douma T B. Evaluating the Antidepressant Effect of Verbena officinalis L. (Vervain) Aqueous Extract in Adult Rats. BCN 2020; 11 (1) :91-98
URL: http://bcn.iums.ac.ir/article-1-1480-fa.html

Introduction: The present study aimed to investigate the antidepressant effect of Verbena (V.) officinalis L. aqueous extract in adult female rats. 
Methods: The present study evaluated the antidepressant effect of V. officinalis L. aqueous (V AE) extract in female rats using the Forced-Swimming Test (FST), Light-Dark Box (LDB) test, and Open Field Test (OFT). The level of glycemia and histological analysis were also studied. The VAE [200 mg/kg Parenterally (PO)] was administered orally for 7 successive days in the separate groups of rats. 
Results: The oral administration of V. officinalis L. aqueous extract significantly decreased (P< 0.01) the immobility time in the FST, increased the time spent in the light area (LDB), and the number of entry into the central squares (OFT). Thus, the extract at a dose of 200 mg/kg significantly decreased the glycemia level (P<0.05) and suggested no harmful effect on brain histology.
Conclusion: Verbena officinalis L. aqueous extract at a dose of 200 mg/kg could have an anti-depressant effect in adult rats.