دوره 9، شماره 5 - ( September & October 2018 1397 )                   جلد 9 شماره 5 صفحات 0-0 | برگشت به فهرست نسخه ها


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Ahmadian N, Hejazi S, Mahmoudi J, Talebi M. Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation. BCN. 2018; 9 (5)
URL: http://bcn.iums.ac.ir/article-1-1039-fa.html
Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation. مجله علوم اعصاب پایه و بالینی. 1397; 9 (5)

URL: http://bcn.iums.ac.ir/article-1-1039-fa.html


چکیده:  
Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer’s. Several studies have indicated that restricted sleep increases the level of deposition of β-amyloid and formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer disease. The mechanisms by which sleep deprivation affects the pathology of Alzheimer disease has not yet been fully and definitively identified. However, risk factors like apolipoprotein E risk alleles, kinases and phosphatases dysregulation, reactive oxygen species, endoplasmic reticulum damages, glymphatic system dysfunctions and orexinergic system inefficacy have been identified as the most important factors which mediates between the two conditions. In this review, these factors are briefly discussed. 
     
نوع مطالعه: Review | موضوع مقاله: Clinical Neuroscience
دریافت: ۱۳۹۶/۷/۱۳ | پذیرش: ۱۳۹۶/۹/۲۷ | انتشار: ۱۳۹۷/۶/۱۰

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