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1- Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; & Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Anatomy, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3- Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Sleep deprivation (SD) has become a common phenomenon in the modern societies. Reduced amounts of sleep has elevated the risk for neurodegenerative conditions such as Alzheimer’s disease. Several studies have indicated that restricted sleep increases the level of deposition of beta-amyloid and the formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer’s disease. The mechanisms by which sleep deprivation affects the pathology of Alzheimer's disease has not yet been fully and definitively identified. However, so far, risk factors like apolipoprotein E risk alleles, kinases and phosphatases dysregulation, reactive oxygen species, endoplasmic reticulum damages, glymphatic system dysfunctions and orexinergic system inefficacy have been identified as the most important factors which mediates between the two conditions. In this review, these factors are discussed briefly. 
Type of Study: Review | Subject: Clinical Neuroscience
Received: 2017/10/5 | Accepted: 2017/12/18 | Published: 2018/04/23

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