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1- PhD Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran & Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Neurophysiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Neurophysiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran & Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is accompanied with pain, hyperalgesia and edema. Over production of pro-inflammatory cytokines and activation of intracellular signaling pathways sustain the RA symptoms considerably. There is a close correlation between the expression of cytokines and opioid receptors in the arthritis process. Studies have shown that probiotics via different pathways such as decreasing levels of pro-inflammatory cytokines can alleviate inflammatory symptoms. Then, based on the crucial role of cellular and humoral immunity in induction of RA symptoms and potency of probiotics in modulation of immune responses, the purpose of this study was to investigate the role of probiotic oral administration on behavioral, cellular and molecular aspects of adjuvant-induced arthritis.

Methods: Complete Freund’s adjuvant (CFA)-induced arthritis was caused by single subcutaneous injection of CFA into the rat’s hind paw on day 0. Different doses of probiotics (1/250, 1/500 and 1/1000 (109 CFU/g)) were administered daily (gavage) after CFA injection. Hyperalgesia, edema, serum IL-1β levels, MOR expression and P38MAPK activities were assessed on days 0, 7, 14 and 21 of the study.

Results: The results of this study indicated the potency of effective dose of probiotics (1/500) in reducing hyperalgesia, edema, serum levels of IL-1β and P38MAPK pathway activity during different phases of arthritis and also increasing the expression of mu opioid receptors during chronic phase of arthritis caused by CFA adjuvant.

Conclusion: It seems that probiotics can effectively reduce inflammatory symptoms by inhibiting the intracellular signaling pathway and cytokine production.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/07/10 | Accepted: 2018/03/6 | Published: 2018/04/23

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