Volume 10, Issue 4 (July & August (In Progress) 2019)                   BCN 2019, 10(4): 313-322 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Etaee F, Rezvani-Kamran A, Taheri M, Omidi G, Hasanein P, Komaki A. Comparing the Antinociceptive Effects of Methamphetamine, Buprenorphine, or Both After Chronic Treatment and Withdrawal in Male Rats. BCN. 2019; 10 (4) :313-322
URL: http://bcn.iums.ac.ir/article-1-964-en.html
1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Biology, School of Sciences, University of Zabol, Zabol, Iran.
Abstract:  

Introduction: Methamphetamine (Meth) and Buprenorphine (BUP) modulate pain perception. However, the antinociceptive effects of their interactions, which affect through different systems, are unclear in rats. This study aimed to compare the analgesic effects of Meth, BUP, and their coadministration, as well as the effect of withdrawal from these substances on nociception in male rats.
Methods: In this experiment, 40 male Wistar rats (weight: 250-300 g) were categorized into four groups: control, Meth, BUP, or BUP+Meth. After seven days of treatments, the antinociceptive effects were assessed using the hot plate and the tail flick tests. The differences among the groups were analyzed with ANOVA and Tukey’s post hoc tests. P values less than 0.05 were considered significant.
Results: Meth and BUP increased the reaction times during the hot plate and tail flick tests. The combination of Meth and BUP increased reaction time more than Meth or BUP alone. 
Conclusion: The significantly high reaction times in rats treated with Meth and BUP indicate that these substances have antinociceptive effects. In addition, Meth enhanced the antinociceptive effects of BUP. These synergistic effects might occur through the dopaminergic, serotonergic, and or adrenergic systems.

Full-Text [PDF 720 kb]      
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/06/10 | Accepted: 2018/03/4 | Published: 2019/07/1

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2019 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb