Volume 9, Issue 3 (May & June 2018 2018)                   BCN 2018, 9(3): 187-194 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zamanian Azodi M, Rezaei Tavirani M, Arefi Oskouie A, Mansouri V, Hamdieh M, Nejati N, et al . Introducing Transthyretin as a Differentially Expressed Protein in Washing Subtype of Obsessive-Compulsive Disorder. BCN 2018; 9 (3) :187-194
URL: http://bcn.iums.ac.ir/article-1-913-en.html
1- Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Psychology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:  

Introduction: Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder. 
Methods: In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, washing subtype before and after treatment with fluoxetine and comparing them with 20 healthy female controls.
Results: One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Transthyretin (TTR) protein showed significant expression changes (fold change=1.7, P<0.05). While the expression level of TTR is significantly decreased in OCD patients before any treatments, the trend is partially normalized after treatment with fluoxetine in positive responders. Furthermore, TTR interaction profile shows that the proteins interacting with this protein may get affected as this protein expression trend changes in OCD patients. 
Conclusion: TTR can be considered for further studies to be validated as a potential biomarker for OCD. 

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/02/11 | Accepted: 2017/07/18 | Published: 2018/05/1

References
1. Alonso, P., Gratacos, M., Segalas, C., Escaramis, G., Real, E., Bayes, M., et al. (2011). Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder. Psychoneuroendocrinology, 36(4), 473-83. [DOI:10.1016/j.psyneuen.2010.07.022] [DOI:10.1016/j.psyneuen.2010.07.022]
2. Bindea, G., Mlecnik, B., Hack, H., Charoentong, P., Tosolini, M., Kirilovsky, A., et al. (2009). ClueGO: A Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics, 25(8), 1091-93. [DOI:10.1093/bioinformatics/btp101] [DOI:10.1093/bioinformatics/btp101]
3. Chiaradia, E., Avellini, L., Tartaglia, M., Gaiti, A., Just, I., Scoppetta, F., et al. (2012). Proteomic evaluation of sheep serum proteins. BMC Veterinary Research, 28, 66. [DOI:10.1186/1746-6148-8-66] [DOI:10.1186/1746-6148-8-66]
4. Freitas, C., Ferreira, M. C., Correia, T., Portinha, I., & Correia, Z. (2016). Obsessive-compulsive disorder in childhood and adolescence. European Psychiatry, 33, S495. [DOI:10.1016/j.eurpsy.2016.01.1822] [DOI:10.1016/j.eurpsy.2016.01.1822]
5. Gertsema, K. A., Reichenberg, J., & Ripperger-Suhler, J. (2016). Cutaneous manifestations of psychiatric disorders and management. Therapy in Pediatric Dermatology, 445–53. [DOI:10.1007/978-3-319-43630-2_25] [DOI:10.1007/978-3-319-43630-2_25]
6. Gratacós, M., Real, E., Bayés, M., Labad, J., & López-Solà, C. (2012). Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder. Journal of psychiatry & neuroscience,37(4), 273. [DOI:10.1503/jpn.110109] [DOI:10.1503/jpn.110109]
7. Hasanzadeh, H., Rezaie-Tavirani, M., Seyyedi, S., & Emadi, A. (2015). Proteomics study of extremely low frequency electromagnetic field (50 Hz) on human neuroblastoma cells. Koomesh, 17(1), 233-238.
8. Ingenbleek, Y., & Bernstein, L.H. (2015). Plasma transthyretin as a biomarker of lean body mass and catabolic states. Advances in Nutrition: An International Review Journal, 6(5), 572-80. [DOI:10.3945/an.115.008508] [DOI:10.3945/an.115.008508]
9. Jakobsson, J., Zetterberg, H., Blennow, K., Ekman, C. J., Johansson, A.G., & Landén, M. (2013). Altered concentrations of amyloid precursor protein metabolites in the cerebrospinal fluid of patients with bipolar disorder. Neuropsychopharmacology, 38(4), 664-72. [DOI:10.1038/npp.2012.231] [DOI:10.1038/npp.2012.231]
10. Konuk, N., Tekın, I., Ozturk, U., Atik, L., Atasoy, N., Bektas, S., et al. (2007). Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediators of inflammation, 2007, 65704. [DOI:10.1155/2007/65704] [DOI:10.1155/2007/65704]
11. Lennertz, L., Wagner, M., Grabe, H. J., Franke, P.E., Guttenthaler, V., Rampacher, F., et al. (2014). 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option. European Neuropsychopharmacology, 24(1), 86-94. [DOI:10.1016/j.euroneuro.2013.07.003] [DOI:10.1016/j.euroneuro.2013.07.003]
12. Li, J., Cui, J., Wang, X., Ma, J., Niu, H., Ma, X., et al. (2015). An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive–compulsive disorder in a chinese han population. Neuropsychiatric Disease and Treatment,11, 897. [DOI:10.2147/NDT.S75009] [DOI:10.2147/NDT.S75009]
13. Mataix-Cols, D., Wooderson, S., Lawrence, N., Brammer, M. J., Speckens, A., & Phillips, M. L. (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Archives of General Psychiatry, 61(6), 564-76. [DOI:10.1001/archpsyc.61.6.564] [DOI:10.1001/archpsyc.61.6.564]
14. Miguel, E., Leckman, J., Rauch, S., do Rosario Campos, M., Hounie, A., Mercadante. M., et al. (2005). Obsessive-compulsive disorder phenotypes: Implications for genetic studies. Molecular Psychiatry, 10(3), 258-75. [DOI:10.1038/sj.mp.4001617] [DOI:10.1038/sj.mp.4001617]
15. Nejadi, N., Hantoushzadeh, S., Masti, S. M., Hosseini, Z.S., Mousavi, M., Gorgani-Firuzjaee, S., et al. (2015). Vitamin D Binding Protein as screening biomarker candidate for late-onset preeclampsia without intrauterine growth restriction during 16 week of gestation. Journal of Paramedical Sciences, 6(1). doi: 10.22037/jps.v6i1.8182
16. Nejadi, N., Masti, S. M., Tavirani. M. R., & Golmohammadi, T. (2014). Comparison of three routine protein precipitation methods: acetone, TCA/acetone wash and TCA/acetone. Journal of Paramedical Sciences, 5(4), 11-15. doi: 10.22037/jps.v5i4.7699
17. Rezaei Tavirani, M., Rahmati Rad, S., Rezaei Tavirani, M. (2016). Ethanol and cancer induce similar changes on protein expression pattern of human fibroblast cell. Iranian Journal of Pharmaceutical Research, 15, 175-84. [PMID] [PMCID] [PMID] [PMCID]
18. Rezaei Tavirani, M., Tadayon, R., Mortazavi, S.A., Medhet, A., Namaki, S., Kalantari, S., et al. (2011). Fluoxetin competes with cortisol for binding to human serum albumin. Iranian Journal of Pharmaceutical Research, 11(1), 325-30.
19. Safari Alighiarloo, N., Rezaei Tavirani, M., Taghizadeh, M., Tabatabaei, S.M., & Namaki, S. (2016). Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis. Peer Journal, 4, e2775. [DOI:10.7717/peerj.2775] [DOI:10.7717/peerj.2775]
20. Seidel, A., Arolt, V., Hunstiger, M., Rink, L., Behnisch, A., & Kirchner, H. (1995). Cytokine production and serum proteins in depression. Scandinavian Journal of Immunology, 41(6), 534-38. [DOI:10.1111/j.1365-3083.1995.tb03604.x] [DOI:10.1111/j.1365-3083.1995.tb03604.x]
21. Shahani, M., Daneshi Mehr, F., Tadayon, R., Salavati, B.H., Zadeh-Baghban, A.R.A., & Zamanian, A., et al. (2013). Glucose and fluoxetine induce fine structural change in human serum Albumin. Iranian Journal of Pharmaceutical Research, 12(1), 185-91. [PMID] [PMCID] [PMID] [PMCID]
22. Sousa, J.C., Grandela, C., Fernández Ruiz, J., De Miguel, R., De Sousa, L., Magalhães, A.I., et al. (2004). Transthyretin is involved in depression-like behaviour and exploratory activity. Journal of Neurochemistry,88(5), 1052-8. [DOI:10.1046/j.1471-4159.2003.02309.x] [DOI:10.1046/j.1471-4159.2003.02309.x]
23. Stein, D. J. (2000). Neurobiology of the obsessive–compulsive spectrum disorders. Biological Psychiatry, 47(4), 296–304. [DOI:10.1016/S0006-3223(99)00271-1] [DOI:10.1016/S0006-3223(99)00271-1]
24. Sullivan, G. M., Mann, J. J., Oquendo, M. A., Lo, E. S., Cooper, T. B., & Gorman, J. M. (2006). Low cerebrospinal fluid transthyretin levels in depression: correlations with suicidal ideation and low serotonin function. Biological Psychiatry, 60(5), 500-6. [DOI:10.1016/j.biopsych.2005.11.022] [DOI:10.1016/j.biopsych.2005.11.022]
25. Taylor, S.(2013). Molecular genetics of obsessive–compulsive disorder: A comprehensive meta-analysis of genetic association studies. Molecular Psychiatry, 18(7), 799-805. [DOI:10.1038/mp.2012.76] [DOI:10.1038/mp.2012.76]
26. White, L.R., Vostrov, A., Zarow, C., Sonnen, J., Uyehara-Lock, J., Launer, L.J., et al. (2015). Strong association of a transthyretin snp with late-life cognitive impairment and Alzheimer's brain lesions at autopsy: The honolulu asia aging study (HAAS). Alzheimer's & Dementia, 11(7), 362-3. [DOI:10.1016/j.jalz.2015.06.259] [DOI:10.1016/j.jalz.2015.06.259]
27. Yang, Y., Wan, C., Li, H., Zhu, H., La, Y., Xi. Z., et al. (2006). Altered levels of acute phase proteins in the plasma of patients with schizophrenia. Analytical Chemistry,78(11), 3571-6. [DOI:10.1021/ac051916x] [DOI:10.1021/ac051916x]
28. Zamanian Azodi, M., Mortazavi Tabatabaei, S. A., Mansouri, V., & Vafaee, R. (2016). Metabolite-protein interaction (MPI) network analysis of Obsessive-Compulsive Disorder (OCD) from reported metabolites. Arvand Journal of Health and Medical Sciences, 1(2), 112-20. [DOI:10.22631/ajhms.2016.43223] [DOI:10.22631/ajhms.2016.43223]
29. Zamanian Azodi, M., Rezaei Tavirani, M., Kermani Ranjbar, T., Arefi Oskouie, A., Rezaei Tavirani, M., Rahmati Rad, S., et al. (2015). Pathophysiology, genetics, types, and treatments in obsessive compulsive disorder. Koomesh, 16(4), 475-87.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb