Volume 9, Issue 4 (July & August 2018 2018)                   BCN 2018, 9(4): 251-260 | Back to browse issues page


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Hasanvand A, Ahmadizar F, Abbaszadeh A, Amini-Khoei H, Goudarzi M, Abbasnezhad A et al . The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats. BCN. 2018; 9 (4) :251-260
URL: http://bcn.iums.ac.ir/article-1-906-en.html
1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
2- Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
3- Department of Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
4- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
5- Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract:  
Introduction: According to studies, statins possess analgesics and anti-inflammatory properties. In the present study, we examined the antinociceptive, anti-inflammatory and antioxidative effects of rosuvastatin in an experimental model of Chronic Constriction Injury (CCI).
Methods: Our study was conducted on four groups; sham, CCI (the control group), CCI+rosuvastatin (i.p. 5 mg/kg), and CCI+rosuvastatin (i.p. 10 mg/kg). We performed heat hyperalgesia, cold and mechanical allodynia tests on the 3rd, 7th, 14th, and 21st after inducing CCI. Blood samples were collected to measure the serum levels of Tumor Necrosis Factor (TNF)-α, and Interleukin (IL)-6. Rats’ spinal cords were also examined to measure tissue concentration of Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) enzymes. 
Results: Our findings showed that CCI resulted in significant increase in heat hyperalgesia, cold and mechanical allodynia on the 7th, 14th and 21st day. Rosuvastatin use attenuated the CCI-induced hyperalgesia and allodynia. Rosuvastatin use also resulted in reduction of TNF-α, IL-6, and MDA levels. However, rosuvastatin therapy increased the concentration of SOD and GPx in the CCI+Ros (5 mg/kg) and the CCI+Ros (10 mg/kg) groups compared to the CCI group. 
Conclusion: Rosuvastatin attenuated the CCI-induced neuropathic pain and inflammation. Thus, antinociceptive effects of rosuvastatin might be channeled through inhibition of inflammatory biomarkers and antioxidant properties.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/01/27 | Accepted: 2017/09/26 | Published: 2018/07/1

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