Volume 8, Number 3 (May & June 2017 -- 2017)                   BCN 2017, 8(3): 213-222 | Back to browse issues page




DOI: 10.18869/nirp.bcn.8.3.213

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Kooshki R, Abbasnejad M, Esmaeili-Mahani S, Raoof M. Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats. BCN. 2017; 8 (3) :213-222
URL: http://bcn.iums.ac.ir/article-1-751-en.html

1- MSc Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
2- phD Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
3- PhD Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:  

Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain.
Methods: Orofacial pain was induced by subcutaneous intra lip injection of capsaicin (100 μg). CA1 administration of orexin A and its selective antagonist (SB-334867-A) were performed 20 minutes prior to capsaicin injection. Learning and spatial memory performances were assessed by Morris Water Maze (MWM) task.
Results: Capsaicin treated rats showed impairment in spatial learning and memory. In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated learning and memory impairment in capsaicin-treated rats. Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated learning and memory loss in capsaicin-treated rats. 
Conclusion: The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin –induced spatial learning and memory impairment.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2016/10/14 | Accepted: 2017/01/24 | Published: 2017/05/1

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