Volume 7, Issue 2 (Spring 2016 -- 2016)                   BCN 2016, 7(2): 137-142 | Back to browse issues page




DOI: 10.15412/J.BCN.03070207
PMID: 27303608
PMCID: PMC4892318

Cited 1 time in PubMed Central

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Davami M H, Baharlou R, Ahmadi Vasmehjani A, Ghanizadeh A, Keshtkar M, Dezhkam I et al . Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder. BCN. 2016; 7 (2) :137-142
URL: http://bcn.iums.ac.ir/article-1-640-en.html

1- Department of Immunology and Microbiology, School of Medicin, Jahrom University of Medical Sciences, Jahrom, Iran.
2- Department of Psychiatry, School of Medicin, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Psychiatry, School of Medicin, Jahrom University of Medical Sciences, Jahrom, Iran.
4- Department of Student Research Committee, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
Abstract:  

Introduction: Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls.
Methods: Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA.
Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-&beta; level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/mL (P>0.05).
Conclusion: Considering pro-inflammatory cytokines, current results support the associationof inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2015/04/6 | Accepted: 2015/08/15 | Published: 2016/04/1

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