Volume 6, Issue 4 (Automn 2015 -- 2015)                   BCN 2015, 6(4): 299-305 | Back to browse issues page


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Derakhshanrad N, Saberi H, Tayebi Meybodi K, Taghvaei M, Arjmand B, Aghayan H R, et al . Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury. BCN. 2015; 6 (4) :299-305
URL: http://bcn.iums.ac.ir/article-1-556-en.html

1- M.D., PhD Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- MD, MPH. Brain and Spinal Cord Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Keshavarz Blvd., Tehran, Iran.
3- M.D. Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
4- M.D.,PhD Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
5- MS Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
6- PhD Department of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
7- MS Department of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
Abstract:  

Introduction: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program.

Methods: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor (G-CSF) along with rehabilitation program. The neurological outcomes as well as safety issues have been reported. 

Results: Assessment with American Spinal Injury Association (ASIA), showed neurological improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication. 
Discussion: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal Stem Cells (MSCs) was safe in our case as an adjunct to conventional rehabilitation programs. Further controlled studies are needed to find possible side effects, and establish net efficacy.
Type of Study: News and Reports | Subject: Cellular and molecular Neuroscience
Received: 2015/06/22 | Accepted: 2015/09/23 | Published: 2015/10/1

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