Volume 5, Number 1 (Winter 2014 -- 2014)                   BCN 2014, 5(1): 11-17 | Back to browse issues page



PMID: 25436078
PMCID: PMC4202599

Cited 2 times in PubMed Central

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Ashok Kumar B, Lakshman K, Velmurugan C, Sridhar S, Gopisetty S. Antidepressant Activity of Methanolic Extract of Amaranthus Spinosus. BCN. 2014; 5 (1) :11-17
URL: http://bcn.iums.ac.ir/article-1-462-en.html

1- Department of Pharmacognosy, Sri K.V.College of Pharmacy, Chickballapur, Karnataka,India.
2- Department of Pharmacognosy, PES College of Pharamcy, Bangalore, Karnataka, India.
3- Department of Pharmacology, Sree Krishna Chaitanya College of Pharmacy, Madanapalle, Andhrapradesh, India.
4- Department of Pharmacology, Sri K.V.College of Pharmacy, Chickballapur, Karnataka, India.
Abstract:  

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Amaranthus spinosus was investigation for antidepressant activity. 

Methods: Antidepressant activity of methanolic extract of Amaranthus spinosus (MEAS) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. Escitalopram and Imipramine were used as reference standards. 
Results: It has been observed from our study that both the MEAS at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to Escitalopram and Imipramine. 
Discussion: However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2013/04/3 | Accepted: 2013/07/4 | Published: 2014/01/1

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