Volume 4, Issue 2 (Spring 2013 -- 2013)                   BCN 2013, 4(2): 153-158 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kakoolaki S, Selamoglu Z, Oguz T, Cakir O, Ciftci O, Ozdemir I. Role of Propolis on Oxidative Stress in Fish Brain. BCN 2013; 4 (2) :153-158
URL: http://bcn.iums.ac.ir/article-1-363-en.html
Abstract:  

Introduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main chemical classes found in propolis are flavonoids and phenolics. Bioflavonoids are antioxidant molecules that play important roles in scavenging free radicals, which are produced in neurodegenerative diseases and aging.

Methods:

To determine the protective role of propolis, rainbow trouts were treated with cypermethrin, followed by biochemical analyses of brain tissue. Fish were divided into four groups: control, propolis-treated, cypermethrin-treated, and cypermethrin+propolis-treated.

Results:

In fish brains, catalase (CAT) activity decreased (P≤0.001) and malondialdehyde (MDA) level increased (P≤0.001) in cypermethrin-treated group compared to control group. In cypermethrin + propolis-treated group CAT activity increased (P≤0.001) and MDA level decreased (P≤0.001) compared to cypermethrin group.

Discussion:

The results demonstrated that the negative effects, observed as a result of cypermethrin treatment, could be reversed by adding supplementary propolis. Propolis may improve some biochemical markers associated with oxidative stress in fish brain, after exposure to cypermethrin.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2013/03/28 | Accepted: 2013/08/23 | Published: 2013/08/23

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb