Volume 5, Number 2 (Spring 2014 2014)                   BCN 2014, 5(2): 138-143 | Back to browse issues page



PMCID: 27545646

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Rahimi Shourmasti F, Goudarzi I, Abrari K, Elahdadi Salmani M, Lashkarboluki T. Riluzole Ameliorates Harmaline-Induced Tremor in Rat. BCN. 2014; 5 (2) :138-143
URL: http://bcn.iums.ac.ir/article-1-345-en.html

1- MS.c School of Biology, Damghan University, Damghan,Iran.
2- Ph.D School of Biology, Damghan University, Damghan,Iran.
Abstract:  

Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Material and Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded. Results: The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor. Discussion: It is concluding that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.

Keywords: Harmaline, Tremor, Riluzole, Rat
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2013/02/25 | Accepted: 2013/07/10 | Published: 2014/04/1

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