Volume 4, Number 1 (Winter 2013 -- 2013)                   BCN 2013, 4(1): 31-35 | Back to browse issues page



PMID: 25337325
PMCID: PMC4202555

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Moghimi A, Mollazadeh S, Behnam Rassouli F, Shiee R, Khalilzade M A. The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics. BCN. 2013; 4 (1) :31-35
URL: http://bcn.iums.ac.ir/article-1-310-en.html

1- The Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren), Ferdowsi University of Mashhad, Iran
2- Biotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
3- Cell and Molecular Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
4- Department of Signal and Systems, Chalmers University, Sweden.
5- Mohammad Ali Khalilzade
Abstract:  

 Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects.

Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others.

Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups.

Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and .nd new effective substance against this kind of epilepsy.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2012/12/18 | Accepted: 2013/03/2 | Published: 2013/03/2

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