Volume 3, Issue 4 (Summer 2012-- 2012)                   BCN 2012, 3(4): 60-67 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moghadami M, Moghimi A, Ahangar E, Jalal R, Rassouli M B, Mahdavi Shahri N. Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult Rats . BCN. 2012; 3 (4) :60-67
URL: http://bcn.iums.ac.ir/article-1-256-en.html
Abstract:  

Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences were observed among females. In addition, no significant behavioral alterations between male and female animals were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavioral abnormalities in adults.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2012/08/2

Add your comments about this article : Your username or Email:
Write the security code in the box

© 2015 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb