Volume 3, Number 2 (Winter 2012 -- 2012)                   BCN 2012, 3(2): 12-15 | Back to browse issues page


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Alipanahzadeh H, Soleimani M, Soleimani Asl S, Mehdizadeh M. The Effect of TGF-alpha on Neurogenesis in Subventricular Zone of Rat Brain after Ischemia-Reperfusion. BCN. 2012; 3 (2) :12-15
URL: http://bcn.iums.ac.ir/article-1-208-en.html

Abstract:  

Introduction:

Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After induction of ischemia-reperfusions, PBS (phosphate buffer salin) and TGF-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. After 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method.

Results:

Our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p<0.05) .

Discussion:

Expression of nestin in SVZ indicates that TGF- α can stimulate the neural stem cells proliferation after ischemia –reperfusion injury.

Methods:

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/04/19

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