google-site-verification=NjYuzjcWjJ9sY0pu2JmuCKlQLgHuwYq4L4hXzAk4Res The Effects of Boswellia Resin Extract on Dopaminergic Cell line SK-N-SH against MPP+-Induced Neurotoxicity - Basic and Clinical Neuroscience
Volume 3, Issue 1 (Autumn 2011 -- 2011)                   BCN 2011, 3(1): 16-21 | Back to browse issues page

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Kazmi S, Kafami L, Ebrahimi A, Jameie B, Joghataiee M T. The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity. BCN 2011; 3 (1) :16-21
URL: http://bcn.iums.ac.ir/article-1-192-en.html
The Effects of Boswellia Resin Extract on Dopaminergic Cell line, SK-N-SH, against MPP+-Induced Neurotoxicity
Sareh Kazmi * , Laya Kafami , Ahmad Ebrahimi , Behnam Jameie , Mohammad Taghi Joghataiee
Abstract:  

Introduction: Oxidative stress and neuroinflammation are involved in neurodegeneration procedure in Parkinson’s disease. Recently, neuroprotective potential of Boswellia resin has been demonstrated. Therefore, this study examined whether administration of Boswellia resin would attenuate MPP+- induced neuronal death in SK-N-SH- cell line, a human dopaminergic neurons- in vitro.

Methods:

Boswellia resin extract was added to culture medium (10μg/ml) before and after exposure of SK-N-SH cell line to MPP+ (1000μM). Cell viability and apoptosis features were assessed using MTT and Hoechst staining, respectively.

Results:

Treatment with Boswellia resin 2 and 3h prior to MPP ° exposure and up to 60 minutes after MPP ° exposure significantly increased cell viability compare to untreated cells. Apoptotic features were also reduced significantly by Boswellia resin (10 μg/ml) compare to that of control untreated cells.

Discussion:

Boswellia resin has neuroprotective effects on dopaminergic neurons which can be applicable in Parkinson’s disease.

Keywords: Parkinson’s Disease, Boswellia Resin, SK-N-SH Cell Line, MPP°
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Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/03/29 | Published: 2011/10/15
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