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1- Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
2- Department of Psychology, Faculty of Humanities, Islamic Azad University Firoozabad Branch, Fars, Iran.
3- Department of Microbiology, Karaj Branch Islamic Azad University, Karaj, Iran
4- Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
5- Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Objective: The increase in the number of patients with Alzheimerchr('39')s disease (AD) has led to numerous problems. The risk of developing AD increases in menopause women. Apigenin and is β-estradiol are effective antioxidant and neuroprotective agents. In order to study the combined effects of them on beta-amyloid plaque formation, memory, and learning in ovariectomized rats, the present study was designed.
Methods: Forty-two Wistar rats were randomly assigned into 7 groups;  ovariectomized  (OVX), OVX + apigenin, OVX + β-estradiol, OVX + apigenin +  β-estradiol, vehicle and surgical sham. Treatment was done with apigenin and β-estradiol. The formation of β-amyloid plaques, neuronal density in the hippocampus area, apoptosis, memory, and learning was studied.
Results: Findings showed the significant formation of β-amyloid plaques in the (hippocampus) area of OVX animals and memory impairment.  Apigenin and β-estradiol significantly reduced the number of β-amyloid plaques, as well as the reduction of symptoms of memory impairment and learning and decreased expression of Caspase-3 in treated animals.  
Conclusion: Accordingly, the combination of antioxidants with E2 could have more strong therapeutic effects for AD.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2020/06/12 | Accepted: 2020/08/9

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