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1- Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran
2- Student Research Committee, Qom University of Medical Sciences, Qom, Iran
3- Department of Cardiology, Qom University of Medical Sciences, Qom, Iran
Abstract:  
Introduction: Recent studies have shown that polyunsaturated fatty acids (PUFAs; including eicosapentaenoic acid [EPA], and arachidonic acid [AA]), are associated with cognitive functions in patients with disease coronary artery disease (CAD). Nevertheless, controversial results have been reported. The aim of the current study was to clarify the association of serum EPA and AA levels with cognitive decline in an Iranian samples with CAD.
Methods: We evaluated cognitive function with the mini-mental state examination (MMSE), and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated.
Results: Patients with CAD generally had mild cognitive impairment. But we couldnchr('39')t find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI; and the correlation between sex and MMSE/MoCA was significant too.
Conclusion: Subjects generally had mild cognitive impairment, but we couldnchr('39')t find any significant correlation between serum EPA and AA levels with cognitive function.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2020/04/16 | Accepted: 2020/07/19

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