Volume 12, Issue 1 (January & February 2021)
BCN 2021, 12(1): 63-68 |
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Yoosefee S, Rahimi M, Razavinia F S, Vahedian M, Bagheri A R. Serum Eicosapentaenoic and Arachidonic Acids Concentration and Cognitive Function in Patients With Coronary Artery Disease. BCN 2021; 12 (1) :63-68
URL: http://bcn.iums.ac.ir/article-1-1752-en.html
URL: http://bcn.iums.ac.ir/article-1-1752-en.html
Sadegh Yoosefee1 
, Maryam Rahimi1 , Fatemeh Sadat Razavinia2 , Mostafa Vahedian3 , Ahmad Reza Bagheri * 4
, Maryam Rahimi1 , Fatemeh Sadat Razavinia2 , Mostafa Vahedian3 , Ahmad Reza Bagheri * 4
1- Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
2- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
3- Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran.
4- Department of Cardiology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
3- Research Center for Environmental Pollutants, Qom University of Medical Sciences, Qom, Iran.
4- Department of Cardiology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Abstract:
Introduction: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline in an Iranian sample with CAD.
Methods: We evaluated cognitive function with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated.
Results: Patients with CAD generally had mild cognitive impairment. But we could not find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI. Finally, the correlation between sex and MMSE/MoCA was significant.
Conclusion: Subjects generally had mild cognitive impairment, but we could not find any significant correlation between serum EPA and AA levels with cognitive function.
Methods: We evaluated cognitive function with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated.
Results: Patients with CAD generally had mild cognitive impairment. But we could not find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI. Finally, the correlation between sex and MMSE/MoCA was significant.
Conclusion: Subjects generally had mild cognitive impairment, but we could not find any significant correlation between serum EPA and AA levels with cognitive function.
Keywords: Eicosapentaenoic acid, Arachidonic acid, Cognitive function, Mini Mental State Examination, Montreal cognitive assessment, Coronary artery disease
Type of Study: Original |
Subject:
Clinical Neuroscience
Received: 2020/04/16 | Accepted: 2020/07/19 | Published: 2021/01/1
Received: 2020/04/16 | Accepted: 2020/07/19 | Published: 2021/01/1
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