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1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
3- Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
4- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
5- Cellular and molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Background:Extremely low-frequency electromagnetic fields(ELF-EMFs)have gathered significant consideration for their possible pathogenicity.However, their effects on nervous system functions were not fully clarified. In this study,our aim was to know the functions of ELF-EMFs exposure on learning, memory, anxiety, antioxidant activity, beta amyloid deposition and microglia population in rats.
Materials and Methods:Fifty male adult rats were randomly separated into 5 groups; four groups exposed to a flux density of 1, 100, 500 and 2000 microtesla (µT), 50 Hertz (Hz)frequency for 1h/day for 2 months and one group as a control group. Animals in control group were placed in a same chamber without exposure to ELF-EMF. After 8 weeks, passive avoidance task was performed to assess the cognitive ability and memory formation.Elevated plus maze test was also performed to evaluate the anxiety-like behavior.Serum capacity, total free thiol groups and the index of lipid peroxidation were assessed.Also, for detection of β-Amyloid deposition and staining microglia in the brain, anti-β-amyloid and anti-Iba1 antibodies were used respectively.
Results:Cognitive ability and memory formation were improved after exposure to ELF-EMFs. No β-Amyloid depositions were detected in the hippocampus of different groups and increasing in frequency of microglial cells in the 100, 500 and 2000 µT groups was considerable compared with the control and 1 µT group.
Conclusion:Exposure to ELF-EMF has an anxiogenic effect on rats and promotes memory and long-term retention and also induced oxidative stress. No β-Amyloid depositions were detected in the brain. Also, positive effect of ELF-EMF was observed on frequency of microglia population in the brain.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2020/03/28 | Accepted: 2020/06/8

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