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1- Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Pharmacology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY 10032, United States of America
4- Department of Anatomical Sciences , Faculty of Medicine, Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:  
Abstract
Introduction: Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Neuroprotective strategies reported to attenuate cognitive deficits after ischemic events. Here we investigated the neuroprotective potential of chrysin in a rat model of cerebral ischemia reperfusion (I/R) in the presence or absence of estrogen receptors (ERs) activities.
Methods: Adult male Wistar rats were pretreated with Chrysin (CH; 30mg/kg; gavage; for 21 consequence days) alone or with selective ERs antagonists (ERα antagonist MPP; ERβ antagonist PHTPP) or non-selective ERs antagonist (ICI182780). Then, the bilateral common carotid arteries were occluded for 20 min, which was followed by reperfusion. Subsequently, cognitive performance was evaluated by Morris water maze (MWM) and Shuttle Box tasks, and afterward, hippocampi were removed for ELISA assays and H&E staining. Oxidative indicators malondialdehyde, (MDA) and glutathione peroxidase (GPx), as well as inflammation mediators TNFα and IL-1β were measured using commercial kits.
Results: Results of the current study that both anti-oxidative and anti-inflammatory properties of CH are possible mechanisms that improved cognitive deficits and prevent neuronal cell death following I/R. These effects were reversed by ICI182,780. Furthermore, when chrysin was co-treated with ERβ antagonist PHTPP showed a weak neuroprotective effect in I/R rats. However, these parameters were not significantly different when chrysin was combined with ERα antagonist MPP.  
Conclusion: Our data confirm that chrysin could potentially serve as a neuroprotective agent against devastating effects of cerebral I/R injury, which may be mediated via its interaction with ERs, especially ERβ.
Type of Study: Original | Subject: Cognitive Neuroscience
Received: 2020/01/24 | Accepted: 2020/04/19

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