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Abstract:  
Introduction: ­Corticotropin releasing hormone ­(CRH) involves in both stress and energy homeostasis. On the other hand, receptors of CRH also exist within the paraventricular nucleus ­­(PVN) and central amygdala­(CeA) nuclei. The present study compared the effect of CRH microinjections into PVN and CeA on three consecutive hours and cumulative food intake, internal regulatory factors of food intake, such as serum leptin and ghrelin as well as blood glucose levels in rats under different acute psychological (social and isolation; SS, IS group) stresses.
Methods: ­Sixty-six male Wistar rats were randomly allocated to eleven groups: Control, Sham, CRH-PVN, CRH-CeA, SS, IS, SS-CRH-PVN, SS-CRH-CeA, IS-CRH-PVN and IS-CRH-CeA groups. The CRH ­(2µg/kg in 0.5µl saline) injected into both PVN and CeA nuclei in rats under normal condition and acute social and isolation stresses.
Results: ­Acute isolation and social stresses did not affect cumulative food intake. Whereas, isolation stress led to changes in both leptin and glucose levels, the social stress reduced only glucose level. Cumulative food intake significantly decreased under acute CRH injection into the CeA and particularly into the PVN. Blood glucose significantly decreased in all the groups receiving CRH into their CeAs.
Conclusion:­ The PVN played a more important role compared to CeA on food intake. These nuclei probably have employed different mechanisms for their effects on food intake. In addition, it seems that exogenously CRH injection into the PVN probably had a more anorectic effect than naturally activated CRH by stresses. Acute isolation stress had a greater effect than social stress on leptin level and cumulative food intake. Thus, elevated food intake related to leptin compared to ghrelin and glucose levels in the CRH-PVN group under acute social stress.
 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2020/01/18 | Accepted: 2020/06/28 | Published: 2018/03/15

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