Accepted Articles                   Back to the articles list | Back to browse issues page


XML Print


1- Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2- Brachial Plexus and Peripheral Nerve Injury Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Department of Neuroscience, Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran and School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
4- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:  
Introduction: Epilepsy is one of the most common neurological disorders. Though there are effective medications available for treatment of epilepsy, the use of most drugs is associated with many side effects and drug interactions. Stachys lavandulifolia (SL) used in Iranian traditional medicine show anti-anxiety and sedative actions.  The objective of the current study was to evaluate the anticonvulsant effect of hydroalcoholic extract of SL on the pentylenetetrazole (PTZ)-induced seizure in male mice and the role of benzodiazepine and opioid receptors.
Methods: This study was conducted on 100 male mice randomly categorized into 10 groups: Normal Saline, Diazepam groups (0.025 and 0.1 mg/kg), SL extract groups (50, 100 and 200 mg/kg), Diazepam 0.025 mg/kg + SL extract 50mg/kg and three groups that pre-treated with NS,   Flumazenil or Naloxone, 5 min before injection of 200 mg/kg extract. After 30 min, PTZ (80 mg/kg) was injected to animals and seizure indices were evaluated.
Results: The SL extract attenuated the PTZ-induced seizures in a dose dependent manner and pre-treatment with flumazenil reversed this effect of SL extract but pre-treatment with naloxone could not reverse this effect, because seizure indices on naloxone pretreated group was still lower than normal saline group. Combination of ineffective dose of diazepam and SL extract decrease PTZ-induced seizures.  
Discussion: The results of our study showed the anticonvulsant properties of hydroalcoholic extract of SL. These effects might be due to the impact of the components of this extract on the central benzodiazepine system.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2019/12/29 | Accepted: 2020/08/16

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb