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1- Dept. of Biology, Damghan Branch, Islamic Azad University, Damghan, IRAN
2- Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IRAN
Abstract:  
Introduction: Research has shown that gold nanoparticles (AuNPs) can damage brain tissue physiological processes. Given the antioxidant properties of gingerol (GING), the aim of this study was to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor, nerve growth factor, DNA oxidative damage, and the amount of Bax and Bcl-2 Apoptosis indices of rats exposed to AuNPs.
Methods: Forty two male Wistar rats were divided into four groups: control (30 days 0.5 ml saline), AuNPs (one time injection of 0.5 ml AuNPs, 200 ppm and 60 Nm + 30 days 0.5 ml saline), AuNPs+GING 50 (one time injection of 0.5 ml AuNPs, 200 ppm and 60 Nm + 30 days 0.5 ml density of gingerol 50 mg / kg), AuNPs+GING100 (one time injection of 0.5 ml AuNPs, 200 ppm and 60 Nm + 30 days 0.5 ml density of gingerol 100 mg / kg). At the end of the treatment period, the hippocampal levels of NGF, BDNF, 8-HodG and Apoptotic indices of Bax and Bcl-2 were assessed through ELISA method.
Results: Compared with the AuNPs group, hippocampal levels of BDNF, NGF, and Bcl-2 in rats from AuNPs+GING 50 and AuNPs+GING 100 groups significantly increased depending on the dose of injection. The hippocampal levels of Bax and HOdG-8 significantly decreased in a dose-dependent manner (P < 0.05).
Conclusion: According to obtained results, it may be suggested that gingerol improves hippocampal BDNF and NGF levels in rats exposed to AuNPs maybe by reducing apoptosis and oxidative DNA damage.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2019/10/13 | Accepted: 2020/04/4 | Published: 2018/03/15

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