Accepted Articles                   Back to the articles list | Back to browse issues page

XML Print


Abstract:  
Introduction: Obsessive-compulsive disorder (OCD) is one of the complex neuropsychiatric conditions. This disorder disables individuals in many different aspects of their personal and social life. Interactome analysis may provide a better understanding of this disorder molecular origin and its underlying mechanisms.
Methods: Here, the OCD associated genes were extracted from the literature. The criterion for gene selection was to choose genes with at least one significant report. Furthermore, by the application of Cytoscape and its plug-ins, protein-protein interaction network and gene ontology of the 31 candidate genes related to OCD from genetic association studies is examined. The cross-validation method was used for network centrality assessment.
 
Results: A scale-free network including 1940 nodes and 3269 edges for 31 genes was constructed.  According to the network centrality evaluation, ESR1, TNFα, DRD2, DRD4, HTR1B, HTR2A, and CDH2 showed the highest values, and therefore can be considered as hub-bottlenecks elements. It is also confirmed by the number of 123 cross-validation tests that the frequency of these essential genes remains unaltered against the initial seed genes’ changes with the accuracy of 0.962.  In addition, enrichment analysis identified four highlighted biological processes related to the 31 candidate genes. The top biological processes are determined as dopamine transport, learning, memory, and monoamine transport.
 
Conclusion: Among 31 initial genes, seven of them are introduced as crucial elements for onset and development in OCD and can be suggested for further investigations. Furthermore, the complex molecular origin of OCD purpose the requirement of high-throughput screening for diagnosis and treatment goals. The findings are possible useful source to establish molecular-based diagnostic tool for OCD.    
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2019/08/23 | Accepted: 2019/12/2 | Published: 2018/03/15

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2020 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb