دوره 13، شماره 6 - ( 8-1401 )                   جلد 13 شماره 6 صفحات 814-807 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Safari A, Fadakar N, Borhani-Haghighi A. The Association Between Inflammatory Biomarkers and Vitamin D Level With the Evolution and Severity of Stroke. BCN 2022; 13 (6) :807-814
URL: http://bcn.iums.ac.ir/article-1-1577-fa.html
The Association Between Inflammatory Biomarkers and Vitamin D Level With the Evolution and Severity of Stroke. مجله علوم اعصاب پایه و بالینی. 1401; 13 (6) :807-814

URL: http://bcn.iums.ac.ir/article-1-1577-fa.html


چکیده:  
Introduction: Vitamin D deficiency has been linked to the evolution of ischemic stroke, but the data regarding the association between stroke severity and vitamin D level is scarce.
Methods: Patients with first-ever ischemic stroke in the middle cerebral artery territory, within seven days after the stroke, were recruited. The control group included age- and gender-matched individuals. We compared 25-OH vitamin D (vitamin D), high sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), and osteopontin levels between stroke patients and the control group. The association between stroke severity according to the National Institutes of Health Stroke Scale (NIHSS) and the Alberta stroke program early CT score (ASPECTS) and levels of vitamin D and inflammatory biomarkers were also studied.
Results: There was an association between hypertension (P=0.035), diabetes mellitus (P=0.043), smoking (P=0.016), history of ischemic heart disease (P=0.002), higher SAA (P<0.001), higher hsCRP (P<0.001), and lower vitamin D levels (P=0.002) and stroke evolution in a case-control study. Meanwhile, in stroke patients, its severity was associated with higher SAA (P=0.04) and hsCRP (P=0.001), and lower vitamin D levels (P=0.043) according to clinical scale (higher admission NIHSS). According to the ASPECT score, higher SAA (P=0.017) and hsCRP (P=0.007), but not lower vitamin D levels, were associated with more infarct areas (P=0.149).
Conclusion: Vitamin D may play a role in both the evolution and severity of stroke.
نوع مطالعه: Original | موضوع مقاله: Clinical Neuroscience
دریافت: 1398/5/15 | پذیرش: 1398/11/21 | انتشار: 1401/8/10

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Basic and Clinical Neuroscience می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb