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1- Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
2- Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
3- Department of Epidemiology, Ilam University of Medical Sciences, Ilam, Iran
4- Department of Neuroscience, Iran University of Medical Sciences, Tehran, Iran
Abstract:  
Introduction: Oxidative stress plays critical role in aging and pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior is not clarified yet.  Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city.
Methods: 50 suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. In order to consider the oxidant-antioxidant status, serum levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and the total antioxidant capacity (TAC) were measured.
Results: Serum levels of SOD enzyme and TAC were significantly lower in suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters in compare with the controls. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the controls.
Conclusion: Presence of oxidative stress without MDA elevation, which has been detected in suicide attempters can be considered as a biochemical hallmark in suicide behavior.    
 
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2019/07/3 | Accepted: 2020/07/21

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