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1- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Bijand, Iran.
2- Department of neurology, Faculty of medicine, Mashhad University of Medical science, Mashhad, Iran.
3- School of Persian and Complementary Medicine, Mashhad university of Medical sciences, Mashhad, Iran.
4- Endocrine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6- Chinese and Complementary Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
7- Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
8- Metabolic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:  
Objective: Vitamin D may be associated to the modulation of signaling cascade in the central nervous system. We aimed to evaluate the effect of high dose vitamin D supplementation on neuropsychological function in female adolescents.
Methods: We evaluated the effects of 9 weeks of vitamin D supplementation [50000 IU of vitamin D3 (cholecalciferol)/weekly] on cognitive ability and sleep disorders among 940 adolescent girls.
Results: Oral vitamin D supplementation upgraded cognitive abilities tasks including memory, inhibitory control and selective attention, decision making, planning, sustained attention and cognitive flexibility in healthy adolescent girls (p<0.001). The prevalence of subjects with insomnia after intervention fell from 15.0% to 11.3%. Similar results were also found for prevalence of subjects with sleepiness (15.6% decreased to 14.7%), or having cases with both insomnia and sleepiness (8.0% decreased to 6.1%; P<0.05).
Conclusion: High dose vitamin D can improve cognitive abilities and ameliorated insomnia and daytime sleepiness among adolescent girls. Further investigations are needed on a various population group (age and gender) and to establish the sustainability of these effects. The significance of vitamin D therapy in other neurological diseases would also be of interest.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2019/06/27 | Accepted: 2019/09/2

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