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1- Neuroscience Research Center, Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
4- Deputy of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran.
Introduction: Stroke is one of the main cause of disability and the second cause of death worldwide. Among several infectious agents considered as the risk factor of stroke, some pathogens have shown stronger robust associations with stroke. Proposing an accurate correlation between infectious microorganisms and stroke provides valuable information for early intervention and control of the infections.
Methods: In this study, we searched literature using the Web of Science, PMC/Medline via PubMed, and Scopus databases up to July 2018 with no time and language restrictions. After quality assessment, 16 articles were included in the study. The whole data extraction process was conducted by two reviewers independently.
Results: Based on the results of the studies, it seems that viruses such as human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Herpes Simplex virus Type-1, 2 (HSV-1, 2), Varicella-zoster virus (VZV or Chickenpox), and West Nile virus (WNV) are common causes of ischemic stroke. Moreover, the association of other microbial categories such as Streptococcus mutans (in bacteria), Toxoplasma gondii and Toxocara spp. (in parasites), and Rhizopus sp. (in fungi) with stroke was reported.
Conclusion: Considering the adverse role of these microorganisms, it is necessary to implement some prevention measures and methods for stroke treatment.
Type of Study: Review | Subject: Clinical Neuroscience
Received: 2019/06/9 | Accepted: 2020/04/25 | Published: 2018/03/15

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