Volume 11, Issue 6 (November & December 2020)                   BCN 2020, 11(6): 715-726 | Back to browse issues page


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Jafarian M, Alipour M E, Karimzadeh F. Experimental Models of Absence Epilepsy. BCN. 2020; 11 (6) :715-726
URL: http://bcn.iums.ac.ir/article-1-1411-en.html
1- Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Mdical Sciences, Tehran, Iran.
2- Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:  
Introduction: Absence epilepsy is a brief non-convulsive seizure associated with sudden abruptness in consciousness. Because of the unpredictable occurrence of absence seizures and the ethical issues of human investigation on the pathogenesis and drug assessment, researchers tend to study animal models. This paper aims to review the advantages and disadvantages of several animal models of nonconvulsive induced seizure.
Methods: The articles that were published since 1990 were assessed. The publications that used genetic animals were analyzed, too. Besides, we reviewed possible application methods of each model, clinical types of seizures induced, purposed mechanism of epileptogenesis, their validity, and relevance to the absence epileptic patients. 
Results: The number of studies that used genetic models of absence epilepsy from years of 2000 was noticeably more than pharmacological models. Genetic animal models have a close correlation of electroencephalogram features and epileptic behaviors to the human condition.
Conclusion: The validity of genetic models of absence epilepsy would motivate the researchers to focus on genetic modes in their studies. As there are some differences in the pathophysiology of absence epilepsy between animal models and humans, the development of new animal models is necessary to understand better the epileptogenic process and, or discover novel therapies for this disorder.
Full-Text [PDF 1143 kb]      
Type of Study: Review | Subject: Cellular and molecular Neuroscience
Received: 2019/01/21 | Accepted: 2019/12/1 | Published: 2020/11/1

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