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1- Department of Motor Behavior, faculty of Physical Education and Sport Sciences, University of Urmia, Urmia, Iran
2- Department of Motor Behavior, faculty of Physical Education and Sport Sciences, University of Urmia, Urmia, Iran
3- Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract:  
Introduction: Diabetes mellitus has harmful effects on body functions such as learning and memory. According to the role of exercise and medicinal plants on body health, the purpose of this study was to survey the effect of combined aerobic training and use of ripe pistachio hulls (RPH) hydro – alcoholic extract on Learning and memory in streptozotocin – induced diabetic male rats.
Methods: In this experimental study, male Wistar rats weighing 250-280 g were used in 6 groups with equal number of 7 rats in each one. Rats were diabetic with streptozotocin (STZ) (50 mg / kg), and the test protocol was applied for 8 weeks. SPSS software was used to analyze the data and P < 0.05 was significant.
Results: The results showed that (step through latency in acquisition trial, STLa) was not significantly different among groups. While significantly (step through latency in 24 h retrieval, STLr 24) was increased  and (time spent in the dark compartment, TDC) was decreased in treated groups compared to diabetic control groups (p < 0.001). There was no significant difference between STZ and saline diabetic groups.
 Discussion: As the findings of this study showed that the RPH hydroalcoholic extract and aerobic exercise could improve passive avoidance memory in streptozotocin diabetic rats. Therefore, they might be an adjuvant therapy together with other traditional medicine.
 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/11/26 | Accepted: 2019/01/19 | Published: 2018/03/15

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