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1- Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical sciences, Yazd, Iran
2- Shahid Sadoughi University of Medical sciences, Yazd, Iran
3- Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany. Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
4- Department of Anesthesia and intensive care, Shahid Sadoughi University of Medical sciences, Yazd, Iran
5- Department of Psychology, Neuroscience laboratory, University of Tabriz, Tabriz, Iran
Abstract:  
Background
Persistence of post-detoxification problems in drug addiction is one of the disadvantages of the ultra-rapid opioid detoxification (UROD) method. Transcranial direct current stimulation (tDCS) has been introduced in experimental addiction treatment for some years. Results of pilot studies suggest that it might be a promising method for addiction treatment.
Objectives
This study explores the adjunctive application of Transcranial direct current stimulation during treatment of opiate addiction with the ultra-rapid opioid detoxification approach.
Methods
This double blind sham-controlled clinical trial was carried out on patients with substance abuse admitted to the Bahman clinic of Yazd in Iran (March to September- 2014). Forty participants were randomly allocated to treatment and control groups. Two sessions of transcranial direct current stimulation (real or sham) over dorsolateral prefrontal cortices (DLPFC) were applied accompanied by ultra-rapid opioid detoxification.
Withdrawal symptoms and craving were assessed by the Drug Desire Questionnaire (DDQ) and Objective Opiate withdrawal scale (OOWS) prior to ultra-rapid opioid detoxification as well as for the 24- hour interval after ultra-rapid opioid detoxification.
Results
Transcranial direct current stimulation optimized the opiate addiction treatment through craving and the withdrawal syndrome alleviation and.
Conclusions               
The results of the study indicate that prefrontal transcranial direct current stimulation may promote the efficacy of the ultra-rapid opioid detoxification method in opioid addiction.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2018/11/3 | Accepted: 2020/08/25

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