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1- Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3- Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany. Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
4- Department of Anesthesia and Intensive Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5- Department of Psychology, Neuroscience laboratory, University of Tabriz, Tabriz, Iran.
Abstract:  
Background: Persistence of post-detoxification problems in drug addiction is one of the disadvantages of the ultra-rapid opioid detoxification (UROD) method. Transcranial direct current stimulation (tDCS) has been introduced in experimental addiction treatment for some years. Results of pilot studies suggest that it might be a promising method for addiction treatment.
Objectives: This study explores the adjunctive application of Transcranial direct current stimulation during treatment of opiate addiction with the ultra-rapid opioid detoxification approach.
Methods: This double blind sham-controlled clinical trial was carried out on patients with substance abuse admitted to the Bahman clinic of Yazd in Iran (March to September- 2014). Forty participants were randomly allocated to treatment and control groups. Two sessions of transcranial direct current stimulation (real or sham) over dorsolateral prefrontal cortices (DLPFC) were applied accompanied by ultra-rapid opioid detoxification.
Withdrawal symptoms and craving were assessed by the Drug Desire Questionnaire (DDQ) and Objective Opiate withdrawal scale (OOWS) prior to ultra-rapid opioid detoxification as well as for the 24- hour interval after ultra-rapid opioid detoxification.
Results: Transcranial direct current stimulation optimized the opiate addiction treatment through craving and the withdrawal syndrome alleviation and.
Conclusions: The results of the study indicate that prefrontal transcranial direct current stimulation may promote the efficacy of the ultra-rapid opioid detoxification method in opioid addiction.
Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2018/11/3 | Accepted: 2020/08/25

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