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1- Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Abstract:  
ABSTRACT
Purpose: Ethanol is considered an effective agent in reducing brain stroke injury. In this study, we assessed the effects of modafinil along with ethanol as combination therapy on behavioral functions in Wistar rats.
Materials and methods: Right middle cerebral artery occlusion (MCAO) was performed. Rats were mainly divided into nine groups (n=8 in each group). The following groups in this study were as i) MCAO control group (ischemia without treatment), ii) vehicle group, iii) modafinil group which were randomly subdivided into three groups received the different doses of modafinil (10, 30, and 100 mg/kg) for 7 days prior to MCAO, iv) ethanol group received 1.5g/kg ethanol at the time of reperfusion v) modafinil + ethanol group which were further subdivided into three groups received modafinil with different doses (10, 30,100 mg/kg) for 7 days prior to MCAO and ethanol at the time of reperfusion. The motor behavior assessment was measured using the Garcia test after 24h, 48h, and 72h and the elevated body swing test was performed after 48h and 72h. The anxiety and locomotor activity were analyzed by the open-field test after 48h and 72h of post-ischemia.
 Results: The results showed that neurological deficit score, locomotor activity, and unexpected thigmotaxis (anxiety) in ethanol alone treatment, modafinil (in a dose-dependent manner), and ethanol+ modafinil treatment groups were significantly higher than the MCAO control group.
Conclusion: our finding confirmed that modafinil (100 mg/kg) in combination with ethanol (1.5g/kg) is beneficial for the recovery of neurologic functions and locomotor activity before the induction of stroke. 

 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/09/15 | Accepted: 2019/02/16

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